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KMID : 1132720050030030068
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Genomics & Informatics
2005 Volume.3 No. 3 p.68 ~ p.73
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Development of a Knowledge Base for Korean Pharmacogenomics Research Network
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Park Chan-Hee
Lee Su-Yeon
Jung Yong
Park Yu-Rang
Lee Hye-Won
Kim Ju-Han
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Abstract
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Pharmacogenomics research requires an intelligent integration of large-scale genomic and clinical data with public and private knowledge resources. We developed a web-based knowledge base for KPRN (Korea Pharmacogenomics Research Network, http://kprn.snubi. org/). Four major types of information is integrated; genetic variation, drug information, disease information, and literature annotation. Eighteen Korean pharmacogenomics research groups in collaboration have submitted 859 genotype data sets for 91 disease-related genes. Integrative analysis and visualization of the large collection of data supported by integrated biomedical pathways and ontology resources are provided with a
user-friendly interface and visualization engine empowered by Generic Genome Browser.
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KEYWORD
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Pharmacogenomics, Alleles, MeSH, PharmGKB, Goldenpath, Genew, Generic Genome Browser
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